The genotypic characteristics and drug susceptibility profiles of clinical isolates of Mycobacterium tuberculosis recovered from prison hospital patients in the Tula region (central Russia) during 2001 and 2002 are reported. The emergence of multi-drug-resistant tuberculosis (TB) poses a major health risk to the population, with economic implications for TB control. Prisons serve as a continuous source of TB transmission. The results showed that members of the LAM and Beijing families are major contributors to the epidemiological picture of TB in the population studied. The two families of strains accounted for most of the drug-resistant TB in the population. The genotypic characteristics of the M. tuberculosis predominant LAM strain that was responsible for 31 % of TB cases in this setting are presented.

译文

报告了从图拉地区 (俄罗斯中部) 2001年和2002的监狱医院患者中回收的结核分枝杆菌临床分离株的基因型特征和药物敏感性。耐多药结核病 (TB) 的出现对人口构成重大健康风险,对结核病控制具有经济影响。监狱是结核病传播的持续来源。结果表明,LAM和北京家庭的成员是研究人群中结核病流行病学状况的主要贡献者。这两个菌株家族占人群中耐药性结核病的大部分。介绍了在这种情况下导致结核病病例31% 的结核分枝杆菌主要LAM菌株的基因型特征。

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