We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.

译文

我们通过多种感官同时体验世界。为了更好地理解多感官处理的机制,我们询问来自两种感官 (听觉和视觉) 的输入是否可以相互作用并驱动初级视觉皮层 (V1) 的神经回路中的可塑性。使用遗传编码的电压和钙指标,我们发现重合的视听体验会改变小鼠v1 L2/3中神经元的超阈值和亚阈值响应特性。具体来说,我们发现在视听配对后,多模态神经元的子集对配对的听觉刺激产生增强的听觉反应。这种交叉模态可塑性持续数天,并反映在L2/3神经元小功能网络的增强上。我们发现V1通过在感觉驱动的共同活动过程中加强多模式神经元的特定功能组件之间的功能关联来处理同时发生的听觉和视觉事件,从而在皮质网络中留下了许多多感觉经验。

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