Responses of multisensory neurons to combinations of sensory cues are generally enhanced or depressed relative to single cues presented alone, but the rules that govern these interactions have remained unclear. We examined integration of visual and vestibular self-motion cues in macaque area MSTd in response to unimodal as well as congruent and conflicting bimodal stimuli in order to evaluate hypothetical combination rules employed by multisensory neurons. Bimodal responses were well fit by weighted linear sums of unimodal responses, with weights typically less than one (subadditive). Surprisingly, our results indicate that weights change with the relative reliabilities of the two cues: visual weights decrease and vestibular weights increase when visual stimuli are degraded. Moreover, both modulation depth and neuronal discrimination thresholds improve for matched bimodal compared to unimodal stimuli, which might allow for increased neural sensitivity during multisensory stimulation. These findings establish important new constraints for neural models of cue integration.

译文

相对于单独呈现的单个线索,多感觉神经元对感觉线索组合的反应通常会增强或降低,但是控制这些相互作用的规则仍然不清楚。我们检查了猕猴区域MSTd中视觉和前庭自我运动提示的整合,以响应单峰,全等和冲突的双峰刺激,以评估多感觉神经元采用的假设组合规则。双峰响应通过单峰响应的加权线性和很好地拟合,权重通常小于1 (次加性)。令人惊讶的是,我们的结果表明,权重随两个线索的相对可靠性而变化: 当视觉刺激降低时,视觉权重降低而前庭权重增加。此外,与单峰刺激相比,匹配的双峰刺激的调制深度和神经元辨别阈值均得到改善,这可能允许在多感觉刺激期间增加神经敏感性。这些发现为线索整合的神经模型建立了重要的新约束。

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