Model hydroxyapatite (HA) scaffolds with porosities spanning multiple length scales were fabricated by robocasting, a solid freeform fabrication technique based on the robotic deposition of colloidal pastes. Scaffolds of various architectures including periodic, radial, and superlattice structures were constructed. Macropores (100-600 microm) were designed by controlling the arrangement and spacing between rods of HA. Micropores (1-30 microm) and submicron pores (less than 1 microm) were produced within the rods by including polymer microsphere porogens in the HA pastes and by controlling the sintering of the scaffolds. These model scaffolds may be used to systematically study the effects of scaffold porosity on bone ingrowth processes both in vitro and in vivo.

译文

通过robocasting制造了具有多个长度尺度的孔隙率的羟基磷灰石 (HA) 模型支架,robocasting是一种基于胶体糊剂机器人沉积的固体自由形式制造技术。构建了各种体系结构的支架,包括周期性,径向和超晶格结构。通过控制HA杆之间的排列和间距来设计大孔 (100-600微米)。通过在HA糊中加入聚合物微球致孔剂并控制支架的烧结,在棒内产生微孔 (1-30微米) 和亚微米孔 (小于1微米)。这些模型支架可用于系统地研究支架孔隙率对体外和体内骨向内生长过程的影响。

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