The authors investigated 37 patients with established focal epilepsy in terms of the antiepileptic drug (AED) blood levels needed to achieve control or significant abatement of seizures; then they examined the patients by computerized axial tomography (CAT) and grouped them according as they did or did not show evidence of an organic food lesion of the brain. Statistical elaboration of the data revealed that CAT-positive patients required significantly higher mean AED blood levels for clinical effectiveness than did CAT-negative patients; also, single drugs failed to produce control at any plasma level, necessitating recourse to multidrug regimes, significantly more often in the CAT-positive than in the CAT-negative patient group. In the discussion the authors examine the possible reasons for the observed difference of therapeutic responses.

译文

作者调查了37例确定的局灶性癫痫患者的抗癫痫药 (AED) 血液水平,以实现控制或显着减轻癫痫发作; 然后,他们通过计算机轴向断层扫描 (CAT) 检查了患者,并根据他们是否显示出脑部有机食物病变的证据对他们进行了分组。数据的统计说明显示,CAT阳性患者比CAT阴性患者需要更高的平均AED血液水平才能达到临床效果; 此外,单一药物无法在任何血浆水平产生控制,因此需要诉诸多药方案,与猫阴性患者组相比,猫阳性患者组的发生率明显更高。在讨论中,作者研究了观察到的治疗反应差异的可能原因。

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