According to data found in the literature, children born to epileptic mothers on anticonvulsant therapy have an increased perinatal mortality rate, namely 2-3 times the average. The congenital malformations attributed to anticonvulsant drugs cannot fully account for this high mortality rate. A case is described in which a severe bleeding disorder manifested itself in successive offspring. A discussion follows in which this defect in blood coagulation in the newborn and the role played by vitamin K is considered as representing an important and preventable cause of neonatal death and morbidity. Other features of the postnatal syndrome (CNS depression, congenital heart disease, withdrawal symptoms, anemia) are mentioned in the case report. Suggested preventative measures employing vitamin K, folic acid and vitamin D are briefly discussed.

译文

根据文献中发现的数据,抗惊厥疗法的癫痫母亲所生的孩子围产期死亡率增加,是平均水平的2-3倍。归因于抗惊厥药物的先天性畸形不能完全解释这种高死亡率。描述了一个案例,其中严重的出血性疾病在连续的后代中表现出来。随后进行了讨论,其中新生儿的凝血缺陷和维生素k的作用被认为是新生儿死亡和发病率的重要且可预防的原因。病例报告中提到了产后综合征的其他特征 (中枢神经系统抑郁症,先天性心脏病,戒断症状,贫血)。简要讨论了使用维生素k,叶酸和维生素d的建议预防措施。

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