Vitamin B-6 status, assessed by plasma pyridoxal phosphate (PLP) concentrations, and vitamin B-6 concentrations in breast milk were examined in 47 lactating mothers supplemented with different amounts of pyridoxine.HCl (PN.HCl) during pregnancy and the first 6 mo of lactation. PLP concentrations in cord blood and maternal plasma at 2 d postpartum and vitamin B-6 concentration in colostrum were positively correlated with the amount of PN.HCl supplementation prenatally (r = 0.71, p less than 0.001; r = 0.74, p less than 0.001; and r = 0.78, p less than 0.001, respectively). Correlations between the amounts of PN.HCl supplementation postnatally and plasma PLP concentrations increased with the length of supplementation. Plasma PLP concentrations were also correlated with vitamin B-6 concentrations of milk samples, which were obtained on the same day as plasma. PN.HCl supplements between 2.5 and 4.0 mg/d (2.1-3.4 mg PN equivalents) ensured vitamin B-6 adequacy of the mother and maintained relatively saturated concentrations of vitamin B-6 in breast milk.

译文

在怀孕期间和哺乳期前6个月,在47名补充了不同量的吡哆醇的哺乳期母亲中,通过血浆磷酸吡哆醇 (PLP) 浓度和母乳中的维生素B-6浓度评估了维生素B-6状态。产后2 d脐血和孕妇血浆中的PLP浓度以及初乳中的维生素B-6浓度与产前补充PN.HCl的量呈正相关 (r = 0.71,p小于0.001; r = 0.74,p小于0.001; r = 0.78,p小于0.001,分别)。PN.HCl补充量与血浆PLP浓度之间的相关性随补充量的增加而增加。血浆PLP浓度也与牛奶样品的维生素B-6浓度相关,牛奶样品与血浆在同一天获得。PN.HCl补充剂2.5至4.0 mg/d (2.1-3.4 mg PN当量) 确保母亲的维生素B-6充足,并保持母乳中维生素B-6的相对饱和浓度。

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