Growth of weight, length, head circumference and skinfold thickness (subscapular and triceps) from birth to 6 months in 53 large-for-dates (LFD) Chinese babies weighing greater than 4.0 kg at term and born to non-diabetic mothers was investigated and correlated with biochemical indices of maternal glucose tolerance at birth: glycosylated haemoglobin (HbA1), serum corrected fructosamine and the area under the oral glucose (50 g) tolerance (OGTT) curve. Growth in all physical dimensions, especially weight, showed a downward shift towards a reference mean. These changes in relative size were caused by slower growth velocities. None of the mothers had abnormally high concentrations of HbA1 or fructosamine nor an abnormal OGTT. However, weight velocities did show small but significant correlations with fructosamine (r = -0.42), and OGTT area units (r = 0.39) but not with HbA1. For some macrosomic babies born to apparently normal mothers, birth is seen to interrupt a process operating in prenatal life that accelerates growth. Covert abnormalities of maternal glucose homeostasis could explain this. Abnormal glucose tolerance during pregnancy might therefore be viewed as a continuum extending from (i) its maximum expression, the frankly diabetic state, through (ii) gestational diabetes to (iii) the mother who has no biochemically evident abnormality of glucose homeostasis but who has sufficient alteration to modify fetal growth. Post-natal growth of LFD babies is additional information which, when taken along with other markers of maternal glucose tolerance, might help to identify the mother at later perinatal risk.

译文

重量、长度、对53名足月体重大于4.0千克的中国婴儿和非糖尿病母亲出生时的头围和皮褶厚度 (肩胛下和三头肌) 从出生到6个月进行了调查,并与母亲的生化指标相关出生时糖耐量: 糖基化血红蛋白 (HbA1),血清校正后的果糖胺和口服葡萄糖 (50g) 耐受性 (OGTT) 曲线下的面积。所有物理尺寸 (尤其是体重) 的增长均显示出向参考平均值的向下移动。相对大小的这些变化是由较慢的生长速度引起的。没有母亲的HbA1或果糖胺浓度异常高,也没有OGTT异常。然而,体重速度与果糖胺 (r = -0.42) 和OGTT面积单位 (r = 0.39) 确实显示出较小但显着的相关性,但与hba1无关。对于一些看似正常的母亲所生的大型婴儿来说,出生被认为会中断产前生活中加速生长的过程。母体葡萄糖稳态的隐性异常可以解释这一点。因此,怀孕期间的葡萄糖耐量异常可能被视为一个连续体,从 (i) 其最大表达,坦率地说,糖尿病状态,到 (ii) 妊娠糖尿病到 (iii) 母亲没有生化明显的葡萄糖稳态异常,但有足够的改变来改变胎儿的生长。LFD婴儿的产后生长是其他信息,当与母亲葡萄糖耐量的其他标志物一起使用时,可能有助于识别处于后期围产期风险的母亲。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录