We examined the effect of exercise on postprandial lipemia (PPL) and insulin resistance in individuals with metabolic syndrome. Subjects were 10 hypertriglyceridemia (HTG) males with insulin resistance [age = 40.1 +/- 2.2 years, body weight = 96.3 +/- 3.3 kg, fasting triglyceride (TG) = 263 +/- 25 mg/dl, VO(2)max = 37 +/- 1.1 ml/kg/min, and Homeostatic Model Assessment (HOMA-IR, an index of insulin resistance) = 3.05 +/- 0.40]. Each subject performed a control trial (Ctr, no exercise), and three exercise trials at 40% (40%T), 60% (60%T), and 70% (70%T) of their VO(2)max. The order of trials was randomized and there were 1-2 weeks wash-out period between the trials. All subjects had a fat-meal in each trial. In the exercise trials, subjects jogged on a treadmill for 1 h at a designated intensity 12 h prior to a fat-meal ingestion. Blood samples were taken at 0 h (before the meal), and 2, 4, 6, and 8 h after the meal. The plasma TG, area score under TG concentration curve for over an 8 h-period (TG AUC) after the meal, and HOMA-IR were analyzed. The TG AUC score in 40%T was 30% lower (P = 0.003), 60%T was 31% lower (P = 0.02), and 70%T was 39% lower (P = 0.02) than Ctr. There were no significant differences in the TG AUC scores among the exercise trials (P > 0.05). The insulin concentrations in both 60 and 70%T were lower than Ctr (P < 0.01) which did not differ from 40%T. HOMA-IR in both 60%T (P = 0.041) and 70%T (P = 0.002) were lower than Ctr, but not different from 40%T (HOMA-IR: Ctr = 3.05 +/- 0.40, 40%T = 2.67 +/- 0.35, 60%T = 2.49 +/- 0.31, 70%T = 2.21 +/- 0.27). The results suggest that for physically inactive individuals with metabolic syndrome, exercising at low to moderate intensity may be sufficient to attenuate PPL and increase insulin sensitivity, whereas higher intensity exercise may be needed to normalize blood glucose.

译文

我们研究了运动对代谢综合征患者餐后脂血症 (PPL) 和胰岛素抵抗的影响。研究对象为胰岛素抵抗男性高甘油三酯血症 (HTG) 10例 [年龄 = 40.1 +/- 2.2岁,体重 = 96.3 +/-3.3千克,空腹甘油三酯 (TG) = 263 +/- 25 mg/dl,VO(2)max = 37 +/-1.1毫升/kg/min,稳态模型评估 (homa-ir,胰岛素抵抗指数) = 3.05 +/- 0.40]。每个受试者在其VO(2) 最大值的40% (40% T) 、60% (60% T) 和70% (70% T) 下进行对照试验 (Ctr,无运动) 和三个运动试验。试验顺序是随机的,试验之间有1-2周的冲洗期。在每个试验中,所有受试者都吃了一顿脂肪餐。在运动试验中,受试者在摄入脂肪餐之前以指定的强度在跑步机上慢跑1小时。在餐前0小时,餐后2、4、6和8小时采集血样。分析了餐后8小时内的血浆TG,TG浓度曲线下的面积评分 (TG AUC) 和homa-ir。40% T的TG AUC评分30% 低于Ctr (P = 0.003),60% T 31% 低于Ctr (P = 0.02),70% T 39% 低于Ctr (P = 0.02)。运动试验之间的TG AUC评分无显着差异 (P> 0.05)。60% 和70% T中的胰岛素浓度均低于Ctr (P <0.01),这与40% T没有差异。60% T (P = 0.041) 和70% T (P = 0.002) 的homa-ir均低于Ctr,但与40% T (homa-ir: Ctr = 3.05/- 0.40,40% T = 2.67/- 0.35,60% T = 2.49 +/- 0.31,70% T = 2.21 +/- 0.27)。结果表明,对于代谢综合征的身体不活跃的个体,低至中等强度的运动可能足以减弱PPL并增加胰岛素敏感性,而可能需要高强度的运动才能使血糖正常化。

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