Transnasal butorphanol is effective in relieving migraine and postoperative pain. The extent to which this drug preparation impacts on cognitive and psychomotor performance, as well as mood, has not been examined. Accordingly, the cognitive and psychomotor, subjective, and physiological effects of two clinically relevant doses of transnasal butorphanol (1 and 2 mg) were compared to that of placebo, and a common analgesic drug combination given for pain relief in ambulatory settings, 600 mg of acetaminophen and 60 mg of codeine, in healthy volunteers (n = 10). The larger transnasal butorphanol dose impaired psychomotor performance for up to 2 h, and produced subjective effects for up to 3 h. The smaller dose had no psychomotor-impairing effects, but had subjective effects (including increased ratings of "sleepy"). All three active drug conditions including miosis. These laboratory results suggest that patients should use caution when using the 1-mg dose of transnasal butorphanol, and should curtail certain activities if they administer the 2-mg dose of transnasal butorphanol for analgesia.

译文

经鼻布托啡诺可有效缓解偏头痛和术后疼痛。尚未研究该药物制剂对认知和精神运动表现以及情绪的影响程度。因此,比较了两种临床相关剂量的经鼻布托啡诺 (1和2 mg) 与安慰剂的认知和精神运动,主观和生理作用,以及在门诊环境中用于缓解疼痛的常见镇痛药物组合,对乙酰氨基酚600 mg和可待因60 mg,健康志愿者 (n = 10)。较大的经鼻布托啡诺剂量会损害精神运动能力长达2小时,并产生主观作用长达3小时。较小的剂量没有精神运动损害作用,但具有主观作用 (包括增加 “困倦” 的评分)。所有三种活性药物条件,包括子宫内膜异位症。这些实验室结果表明,患者在使用1-mg剂量的经鼻布托啡诺时应谨慎使用,如果他们使用2-mg剂量的经鼻布托啡诺进行镇痛,则应减少某些活动。

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