The present study aimed to assess switch from immediate-release (IR) to extended-release (XR) quetiapine in terms of efficacy, tolerability, compliance, and quality of life in a sample of patients with mood disorders. Thirty patients, 10 with major depressive disorder and 20 with bipolar disorder, with residual depressive symptoms, who had switched from quetiapine IR (mean 365 mg/day) to XR (mean 373 mg/day), were recruited and evaluated using different psychometric scales, administered at T0 (switch), T1, and T2 (1 and 6 weeks after the switch, respectively). A significant reduction from T0 to T2 of the total scores on the Hamilton depression rating scale (t=2.15; P=0.04), Hamilton anxiety scale (t=3.04; P=0.006), and clinical global impression-severity item (t=2.8; P=0.01) was found. No differences were found in terms of compliance and quality of life. The switch was well tolerated by 2/3 of patients. Most reported side effects were early/central insomnia with day drowsiness (16.7%), increased appetite and weight (8.4%), mild asthenia (4.2%), and constipation (4.2%), which, in two cases, led to switch interruption. Strategies to relieve side effects, including gradual cross-switch, improved switch feasibility. Switch from quetiapine IR to XR seems to be associated with clinical improvement in major depressives with residual symptoms, although some patients may report side effects because of the different pharmacokinetics.

译文

本研究旨在评估情绪障碍患者样本中从即时释放 (IR) 到缓释 (XR) 喹硫平的疗效,耐受性,依从性和生活质量方面的转换。招募了30例从喹硫平IR (平均365 mg/天) 转换为XR (平均373 mg/天) 的患者,其中10例患有重度抑郁症,20例患有双相情感障碍,并使用不同的心理测量量表进行评估,在T0 (切换),T1,和T2 (分别在切换后1周和6周)。发现汉密尔顿抑郁量表 (t = 2.15; P = 0.04),汉密尔顿焦虑量表 (t = 3.04; P = 0.006) 和临床总体印象严重程度项目 (t = 2.8; P = 0.01) 的总得分从T0显着降低至T2。在依从性和生活质量方面没有发现差异。2/3患者对该开关具有良好的耐受性。大多数报告的副作用是早期/中枢性失眠,白天嗜睡 (16.7%),食欲和体重增加 (8.4%),轻度虚弱 (4.2%) 和便秘 (4.2%),这在两种情况下导致切换中断。缓解副作用的策略,包括逐步交叉切换,提高切换的可行性。从喹硫平IR转换为XR似乎与具有残留症状的主要抑郁症的临床改善有关,尽管由于药代动力学的不同,一些患者可能报告副作用。

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