To better explore the clinical heterogeneity of bipolar mood states, we developed a dimensional scale for assessing all mood episodes (depressive, hypomanic, manic, mixed states) using the same tool. The Multidimensional Assessment of Thymic States (MATHYS) (Henry et al., 2008) provides two scores, a total score measuring a level of activation and a sub-score of emotional reactivity. The aim of this study was to establish the appropriate cut-off in total activation versus inhibition and in the emotional reactivity sub-score in bipolar disorders. Patients (n=187) during an acute episode and controls (n=89) filled in the MATHYS. Receiver Operating Characteristic (ROC) curves were obtained to estimate the sensitivity and specificity of the global score and the emotional reactivity sub-score of the MATHYS, in order to differentiate patients from controls. ROC curves showed very satisfactory sensitivity and specificity levels both for the total score and the sub-score of emotional reactivity, thus providing an appropriate cut-off. Concerning the total score between 0 and 200, patients with a score lower than 91 had significant global inhibition and those with a score higher than 109 had significant global activation. Regarding the emotional reactivity sub-score between 0 and 40, patients with a score lower than 16 had significant emotional hyporeactivity and those with a score higher than 24 had significant emotional hyperreactivity. Our results provide cut-offs for the MATHYS to identify patients in an acute phase.

译文

为了更好地探索双相情绪状态的临床异质性,我们使用相同的工具开发了用于评估所有情绪发作 (抑郁,躁狂,躁狂,混合状态) 的维度量表。胸腺状态的多维评估 (MATHYS) (Henry等人,2008) 提供两个分数,测量激活水平的总分和情绪反应性的子分数。这项研究的目的是在双相情感障碍的总激活与抑制以及情绪反应性子评分中建立适当的临界值。急性发作期间的患者 (n = 187) 和对照组 (n = 89) 填充了MATHYS。获得受试者工作特征 (ROC) 曲线,以估计MATHYS的整体评分和情绪反应性子评分的敏感性和特异性,以区分患者与对照组。ROC曲线对情绪反应性的总评分和子评分均显示出非常令人满意的敏感性和特异性水平,从而提供了适当的临界值。关于总得分在0和200之间,得分低于91的患者具有显着的整体抑制,而得分高于109的患者具有显着的整体激活。关于0到40之间的情绪反应性子评分,得分低于16的患者具有显着的情绪低反应性,而得分高于24的患者具有显着的情绪高反应性。我们的结果为MATHYS识别急性期患者提供了截止日期。

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