Serum samples from 224 aboriginal Amazonian Indians were tested for antibodies to HTLV-III/LAV by an indirect immunofluorescence (IF) assay. 9 individuals (4%), 5 of them female, were seropositive by IF and by confirmatory western blotting and radioimmunoprecipitation tests. 3 of the positive sera were collected in 1968. HTLV-III/LAV seropositivity rates varied among the ethnic groups and ranged from 13.3% among the Pemon Indians to 3.3% among the Yanoama tribe. The titres of HTLV-III/LAV antibodies ranged from 1/40 to 1/320. All individuals tested were apparently healthy at the time of the study. None of 211 randomly chosen, healthy blood donors from Venezuelan cities had antibodies to HTLV-III/LAV. The prevalence of specific antibodies among Amazonian Indians suggests the HTLV-III/LAV or a closely related cross-reactive virus may be endemic in this area. The findings also indicate that this virus is indigenous in non-negroid Latin American and negroid tropical populations.

译文

通过间接免疫荧光 (IF) 测定法测试来自224土著亚马逊印第安人的血清样品的htlv-iii/LAV抗体。9例 (4%),其中5例为女性,通过IF以及验证性western印迹和放射免疫沉淀试验呈血清反应阳性。1968年收集3份阳性血清。Htlv-iii/LAV血清阳性率因种族而异,范围从Pemon印第安人的13.3% 到Yanoama部落的3.3%。Htlv-iii/LAV抗体的滴度范围为1/40至1/320。在研究时,所有接受测试的人显然都很健康。来自委内瑞拉城市的211随机选择的健康献血者中没有一个具有针对htlv-iii/LAV的抗体。亚马逊印第安人中特异性抗体的流行表明,htlv-iii/LAV或密切相关的交叉反应病毒可能在该地区流行。研究结果还表明,该病毒在非negroid拉丁美洲和negroid热带人群中是本地的。

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