We studied the influence of aprotinin and soya bean trypsin inhibitor (SBTI) on the inflammatory reaction induced by the implantation of dry sponges in normal Wistar rats and in kininogen-deficient Brown Norway rats, during the first day after the implantation. In normal rats, aprotinin reduced the volume and total protein content of the exudates at 3 h but not thereafter. Aprotinin also markedly reduced the immunoreactive kinins and kallikrein in the exudates. Aprotinin did not modify the volume of the exudates of the Brown Norway rats. SBTI reduced the inflammatory reaction in both rat strains but did not significantly modify the formation of immunoreactive kinins. The inflammatory reaction developed more slowly in Brown Norway rats. The kinin system is thus involved during the first hours of the development of this acute inflammatory reaction. The anti-inflammatory effect of SBTI does not depend on the inhibition of kinin formation.

译文

我们在植入后的第一天研究了抑肽酶和大豆胰蛋白酶抑制剂 (SBTI) 对正常Wistar大鼠和缺乏激肽原的棕色挪威大鼠中干海绵植入诱导的炎症反应的影响。在正常大鼠中,抑肽酶在3小时内减少了渗出物的体积和总蛋白含量,但此后并未减少。抑肽酶还显着降低了分泌物中的免疫反应性激肽和激肽释放酶。抑肽酶不会改变棕色挪威大鼠的渗出物的体积。SBTI降低了两种大鼠品系的炎症反应,但并未显着改变免疫反应性激肽的形成。棕色挪威大鼠的炎症反应发展较慢。因此,在这种急性炎症反应发生的最初几个小时内,激肽系统就参与其中。SBTI的抗炎作用不取决于激肽形成的抑制作用。

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