After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve regeneration. This phenotype-changing process can be viewed as Schwann cell dedifferentiation. Here, we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation in sciatic explants, we found that extracellular ATP inhibits Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Furthermore, the blockage of lysosomal exocytosis in ATP-treated sciatic explants is sufficient to induce Schwann cell dedifferentiation. Together, these findings suggest that ATP-induced lysosomal exocytosis may be involved in Schwann cell dedifferentiation.

译文

神经损伤后,雪旺氏细胞增殖并恢复为支持神经再生的表型。这种表型变化过程可以看作是雪旺细胞去分化。在这里,我们研究了细胞外ATP在华勒变性过程中雪旺细胞去分化和增殖中的作用。使用坐骨外植体中雪旺细胞去分化和增殖的几种标记,我们发现细胞外ATP在华勒变性过程中抑制雪旺细胞去分化和增殖。此外,ATP处理的坐骨外植体中溶酶体胞吐作用的阻断足以诱导雪旺氏细胞去分化。总之,这些发现表明ATP诱导的溶酶体胞吐作用可能与雪旺氏细胞去分化有关。

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