Human milk provides newborns with several physiologically important proteins not found in cow's milk, including bile salt-stimulated lipase (BSSL) that compensates for the reduced lipolytic capability of the newborn intestine. We analyzed the milk of two ethnically distinct groups of women in northern Nigeria and Nepal. The milk of the Nepalese women (n = 36) contained slightly more BSSL activity (mean, 38.8 units/mL) than that of Fulani (n = 48; mean, 30.3 units/mL) and Kanuri (n = 90; mean 27.6 units/mL) women in Nigeria. There was also a weak positive correlation between the BSSL content of the milk and the body mass index (BMI) of the lactating women. The BSSL activity declined with the length of lactation for both well-nourished and undernourished women. The presence of a heat-stable inhibitor of BSSL in cow's milk was also demonstrated. This finding, along with the decrease in BSSL activity postgestation, could be of significance to populations such as the Fulani of the western Sahel who supplement the diets of their infants with unpasteurized cow's milk.

译文

人乳为新生儿提供了几种在牛奶中找不到的生理重要蛋白质,包括胆汁盐刺激的脂肪酶 (BSSL),可补偿新生儿肠道脂分解能力的降低。我们分析了尼日利亚北部和尼泊尔两个不同种族的妇女群体的牛奶。尼泊尔妇女 (n = 36) 的牛奶含有的BSSL活性 (平均38.8单位/mL) 略高于富拉尼 (n = 48; 平均30.3单位/mL) 和卡努里 (n = 90; 平均27.6单位/mL) 尼日利亚妇女。牛奶中的BSSL含量与哺乳期妇女的体重指数 (BMI) 之间也呈弱正相关。营养丰富和营养不足的妇女的BSSL活性随着泌乳时间的延长而下降。还证明了牛奶中BSSL的热稳定抑制剂的存在。这一发现,以及妊娠后BSSL活性的降低,可能对诸如西萨赫勒地区的富拉尼人等人群具有重要意义,他们用未经巴氏消毒的牛奶补充婴儿的饮食。

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