An antibacterial metabolite was isolated from Paenibacillus polymyxa HKA-15, a soybean bacterial endophyte. The purification of the crude metabolite from Paenibacillus polymyxa HKA-15 was done by column chromatography. In TLC, a spot with an R ( f ) value of 0.86 (±0.02) from the purified fraction showed bioactivity against Xanthomonas campestris pv. phaseoli M-5. In SDS-PAGE, the purified antibiotic was separated in the molecular weight range of 3.5 kDa. The exact molecular weight of the active compound was identified as 1,347.7 Da using MS-MS analysis. Infra red spectrum and (1)H NMR analysis showed the presence of amino acids and fatty acids in the active compound. The characterization of the antibacterial compound revealed its lipopeptide nature. In an agar diffusion assay, the crude metabolite showed a broad spectrum of activity, being able to inhibit the growth of the fungal pathogen, Rhizoctonia bataticola, Macrophomina phaseolina and Fusarium udum. A stronger inhibition was observed against bacterial pathogens viz., X. campestris pv.phaseoli M-5, X. campestris pv. phaseoli CP-1-1, Xanthomonas oryzae, Ralstonia solanacearum and Micrococcus luteus.

译文

从大豆细菌内生菌多粘芽孢杆菌HKA-15中分离出一种抗菌代谢物。通过柱色谱法纯化多粘芽孢杆菌HKA-15的粗代谢物。在TLC中,来自纯化级分的R (f) 值为0.86 (± 0.02) 的斑点显示出对黄单胞菌pv的生物活性。M-5。在sdds-PAGE中,纯化的抗生素在3.5 kDa的分子量范围内分离。使用ms-ms分析将活性化合物的确切分子量鉴定为1,347.7 Da。红外光谱和 (1)H NMR分析显示活性化合物中存在氨基酸和脂肪酸。抗菌化合物的表征揭示了其脂肽的性质。在琼脂扩散测定中,粗代谢物显示出广谱的活性,能够抑制真菌病原体,batataticola根瘤菌,菜豆和镰刀菌的生长。观察到对细菌病原体的更强抑制作用,即X. campestris pv.phaseoli M-5,X. campestris pv。菜豆CP-1-1、米黄单胞菌、青枯菌和黄小球菌。

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