We have proposed a transdermal biolistic method to accelerate a powder formulation of drugs to penetrate human skin for the treatment of a range of diseases. One of the key issues for designing and evaluating transdermal biolistic system is ensuing that the powder drugs are delivered into the skin with a controllable velocity range and spatial distribution. The aerodynamics of supersonic nozzles and performance of the delivery system were initially studied, mainly analytically and experimentally. In this paper, computational fluid dynamics is utilized to characterize two existing prototype devices, in order to further investigate the transient gas and particle dynamics in their supersonic nozzles. To validate the implemented numerical approach, calculated pressure histories, two-dimensional flow structures and particle velocity distributions are made and compared with the reported experimental measurements. The key features of gas dynamics, gas-particle interaction and performance of the prototype transdermal biolistics are discussed and interpreted.

译文

我们提出了一种经皮生物注射方法,以加速药物的粉末制剂渗透人体皮肤以治疗一系列疾病。设计和评估透皮生物成像系统的关键问题之一是,将粉末药物以可控的速度范围和空间分布输送到皮肤中。初步研究了超音速喷嘴的空气动力学和输送系统的性能,主要是通过分析和实验进行了研究。本文利用计算流体动力学来表征两个现有的原型设备,以便进一步研究其超音速喷嘴中的瞬态气体和颗粒动力学。为了验证所实施的数值方法,计算了压力历史,二维流动结构和颗粒速度分布,并与报告的实验测量值进行了比较。讨论并解释了气体动力学,气体-颗粒相互作用和原型透皮生物技术性能的关键特征。

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