Four cases of Stevens-Johnson syndrome considered to be induced by methazolamide were reported. In all of the cases, the first signs of Stevens-Johnson syndrome (i.e., swelling of the skin and mucous membranes or slight fever) appeared about 2 weeks after the patient started taking methazolamide (75 or 100 mg/d). After the appearance of erythema, the skin and mucous membrane lesions progressed rapidly and spread over the entire body, even after the patient ended methazolamide treatment and started treatment with prednisolone. During prednisolone treatment, the skin and mucous lesions became bullous, ruptured spontaneously, and dried with crust or erosion. HLA typing was positive for HLA-B59 in 3 of 4 cases. Methazolamide should be prescribed with caution in patients of Japanese or Korean descent.

译文

报道了4例被认为是由甲唑酰胺引起的Stevens-Johnson综合征。在所有情况下,在患者开始服用甲唑胺 (75或100 mg/d) 后约2周出现Stevens-Johnson综合征的第一个迹象 (即皮肤和粘膜肿胀或轻微发热)。出现红斑后,皮肤和粘膜病变迅速进展并扩散到整个身体,即使在患者结束了甲唑胺治疗并开始使用泼尼松龙治疗之后。在泼尼松龙治疗期间,皮肤和粘液病变变为大疱,自发破裂,并伴有结皮或糜烂干燥。4例中有3例HLA分型为HLA-B59阳性。在日本或韩国血统的患者中,应谨慎使用甲唑胺。

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