We compared the effects of the carbonic anhydrase inhibitors methazolamide and acetazolamide (3 mg kg(-1), i.v.) on the steady-state hypoxic ventilatory response in 10 anaesthetized cats. In five additional animals, we studied the effect of 3 and 33 mg kg(-1) methazolamide. The steady-state hypoxic ventilatory response was described by the exponential function: *Vi= G exp(-D P(O2)) + A where *Vi is the inspired ventilation, G is hypoxic sensitivity, D is the shape factor and A is hyperoxic ventilation. In the first group of 10 animals, methazolamide did not change parameters G and D, while A increased from 0.86 +/- 0.33 to 1.30 +/- 0.40 l min(-1) (mean +/- s.d., P = 0.003). However, the subsequent administration of acetazolamide reduced G by 44% (control, 1.93 +/- 1.32; acetazolamide, 1.09 +/- 0.92 l min(-1), P = 0.003), while A did not show a further change. Acetazolamide tended to reduce D (control, 0.20 +/- 0.07; acetazolamide, 0.14 +/- 0.06 kPa(-1), P = 0.023). In the second group of five animals, neither low- nor high-dose methazolamide changed parameters G, D and A. The observation that even high-dose methazolamide, causing full inhibition of carbonic anhydrase in all body tissues, did not reduce the hypoxic ventilatory response is reminiscent of previous findings by others showing no change in magnitude of the hypoxic response of the in vitro carotid body by this agent. This suggests that normal carbonic anhydrase activity is not necessary for a normal hypoxic ventilatory response to occur. The mechanism by which acetazolamide reduces the hypoxic ventilatory response needs further study.

译文

我们比较了碳酸酐酶抑制剂甲唑酰胺和乙酰唑胺 (3 mg kg(-1),静脉注射) 对10只麻醉猫的稳态低氧通气反应的影响。在另外五只动物中,我们研究了3和33 mg kg(-1) 甲唑酰胺的作用。稳态低氧通气反应由指数函数描述: * Vi = G exp(-D P(O2)) A其中 * Vi是吸入通气,G是低氧敏感性,D是形状因子,A是高氧通气。在第一组10只动物中,甲唑酰胺不改变参数G和D,而A从0.86 +/- 0.33增加到1.30 +/- 0.40 l min(-1) (平均值 +/- s.d.,P = 0.003)。然而,随后施用乙酰唑胺使G降低了44% (对照,1.93 +/- 1.32; 乙酰唑胺,1.09 +/- 0.92 l min(-1),P = 0.003),而A没有显示进一步的变化。乙酰唑胺倾向于降低D (对照,0.20 +/- 0.07; 乙酰唑胺,0.14 +/- 0.06 kPa(-1),P = 0.023)。在第二组五只动物中,低剂量或高剂量的甲唑酰胺均未改变参数G,D和A。观察到即使大剂量的甲唑胺也会在所有身体组织中引起碳酸酐酶的完全抑制,但并未降低低氧通气反应,这让人想起其他人先前的发现,该发现表明体外颈动脉体的低氧反应幅度没有变化。这种药物。这表明正常的碳酸酐酶活性对于发生正常的低氧通气反应不是必需的。乙酰唑胺降低低氧通气反应的机制需要进一步研究。

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