Malnutrition is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Body weight is not a reliable evaluation criterium. Body composition which is more useful can be determined routinely using 2 techniquesskinfold thickness anthropometry (Ant) and bioelectrical impedance analysis (BIA). The validity of this last technique has not been demonstrated in patients with COPD. Fat-free mass (FFM) in 58 patients (51 men, 7 women) with stable COPD (FEV1 < 50% of predicted value) was assessed using the 4-skinfold-thickness method (Ant) and BIA (Imp). Statistical analysis included correlation analysis, intraclass correlation coefficient, and the Bland and Altman analysis. Imp-FFM and Ant-FFM correlated well (r = 0.920; p < 0.0001). Intraclass correlation coefficient was high (rI = 0.9065). However, the values were scattered and there was a systematic bias (significant linear regression between the difference in estimates obtained by the 2 methods and the means). As anthropometric measurements are not reliable in the elderly patients, our results suggest that BIA could be a useful tool to determine FFM in patients with COPD. Its validity still has to be tested against a reference method.

译文

营养不良与慢性阻塞性肺疾病 (COPD) 患者预后不良有关。体重不是可靠的评估标准。可以使用2种技术确定更有用的身体成分人体测量 (Ant) 和生物电阻抗分析 (BIA)。在COPD患者中尚未证明最后一种技术的有效性。使用4-皮肤厚度法 (Ant) 和BIA (Imp) 评估了58例 (51名男性,7名女性) 稳定期COPD (FEV1 <预测值的50%) 患者的无脂肪质量 (FFM)。统计分析包括相关分析,组内相关系数以及Bland和Altman分析。Imp-ffm和Ant-FFM相关性良好 (r = 0.920; p <0.0001)。组内相关系数较高 (rI = 0.9065)。但是,这些值是分散的,并且存在系统偏差 (通过两种方法获得的估计值差异与均值之间的显着线性回归)。由于人体测量在老年患者中不可靠,我们的结果表明,BIA可能是确定COPD患者FFM的有用工具。它的有效性仍需对照参考方法进行测试。

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