In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw. In the analgesic test, AGT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection. However, AGT could not affect the NO level which induced by lambda-carrageenan. These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.

译文

在本研究中,我们使用乙酸诱导的扭体反应模型和福尔马林试验研究了甘氨酸番茄根 (AGT) 的水提取物的镇痛作用,使用 λ-角叉菜胶模型研究了AGT的抗炎作用-引起的爪子水肿。为了研究AGT的抗炎机制,我们检测了肝脏中谷胱甘肽过氧化物酶 (GPx) 和谷胱甘肽还原酶 (GRx) 的活性以及水肿爪中丙二醛 (MDA) 和NO的水平。在镇痛试验中,AGT (0.5和1.0 g/kg) 降低了乙酸诱导的扭体反应和福尔马林试验后期的舔痛时间。在抗炎试验中,AGT (0.5和1.0 g/kg) 降低了 λ-角叉菜胶给药后第三,第四,第五和第六小时的爪子水肿,并增加了SOD的活性,注射 λ-角叉菜胶后第三小时,肝组织中的GPx和GRx降低了水肿爪中的MDA水平。然而,AGT不能影响 λ-角叉菜胶诱导的NO水平。这些结果表明AGT具有镇痛和抗炎作用。AGT的抗炎机制可能与通过增加肝脏中SOD,GPx和GRx的活性来降低水肿爪中的MDA水平有关。

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