Osteoporosis is characterized by low bone mass and by changes in the microarchitecture of the bone. This leads to reduced bone stability and altered suscebtibility to fractures. Bone remodelling in healthy persons is characterized by a balance between bone resorption and bone formation. At the cellular level, bone remodelling is regulated by osteoclast and osteoblast activity. During bone loss, there is an imbalance, osteoclast activity being more pronounced. Therefore, the influende of estrogens, Wnt and the RANK/ RANKL/OPG system on osteoclastogenesis and osteoclast activity has been investigated. The RANK/RANKL/OPG-System is actively involved in the differentiation and function of osteoclasts and seems to play a central part in most pathophysiological mechanisms that are active in osteoporosis.

译文

骨质疏松症的特征是骨量低和骨微结构的变化。这会导致骨骼稳定性降低,并改变对骨折的敏感性。健康人的骨重塑的特征是骨吸收和骨形成之间的平衡。在细胞水平上,骨重塑受破骨细胞和成骨细胞活性的调节。在骨丢失期间,存在不平衡,破骨细胞活性更加明显。因此,研究了雌激素,Wnt和RANK/ RANKL/OPG系统对破骨细胞生成和破骨细胞活性的影响。RANK/RANKL/OPG系统积极参与破骨细胞的分化和功能,并且似乎在骨质疏松症中活跃的大多数病理生理机制中起着核心作用。

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