This study tested two hypotheses. First, that breast pumping contributes to the previously observed decrease in ethanol bioavailability in lactating women. Second, that the effects of breast pumping are more pronounced when ethanol is consumed after a meal. The within-subject factor was test condition (fed or fasted) and the between-subject factor was experimental group (pumped before, PB; pumped after, PA). Those randomly assigned to the PB group (N = 8) breast pumped 1 h before drinking, whereas those assigned to the PA group (N = 8) breast pumped 0.6 h after drinking. Pumping before drinking significantly decreased blood ethanol concentration (P < 0.05) and ethanol bioavailability (P = 0.05). Pumping after drinking sped up elimination (P = 0.008), attenuated ethanol-induced hypothermia (P = 0.002), and increased feelings of stimulation (P = 0.03). The effects were more pronounced when ethanol was consumed after a meal. Common neural/hormonal responses to food and suckling may contribute additive effects in altering the pharmacokinetics/pharmacodynamics of ethanol, and perhaps of other drugs, during lactation.

译文

这项研究检验了两个假设。首先,吸乳会导致先前观察到的哺乳期妇女乙醇生物利用度降低。其次,当饭后食用乙醇时,吸乳的效果更加明显。受试者内因素为测试条件 (进食或禁食),受试者间因素为实验组 (泵送前,PB; 泵送后,PA)。那些随机分配到PB组 (N = 8) 的人在饮酒前1小时吸乳,而分配到PA组 (N = 8) 的人在饮酒后0.6小时吸乳。饮用前抽血显著降低血液乙醇浓度 (P < 0.05) 和乙醇生物利用度 (P = 0.05)。饮酒后的抽水加速消除 (P = 0.008),减弱乙醇诱导的体温过低 (P = 0.002) 和增加的刺激感觉 (P = 0.03)。饭后食用乙醇时,效果更加明显。对食物和哺乳的常见神经/激素反应可能会在哺乳期间改变乙醇和其他药物的药代动力学/药效学方面产生累加效应。

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