Thirty-five patients with definite multiple sclerosis (MS) were studied. They underwent neuropsychological testing and magnetic resonance imaging (MRI). The MRI findings at different brain areas levels were compared with the neuropsychological findings. A quantitative system was used to measure MRI-MS lesions. In this series, a positive correlation was established between memory and learning disturbances measured by Battery 144, and the lesions measured by MRI (total, hemispheric and, particularly, periventricular lesions). MRI can detect MS lesions, and this study shows that a correlation between MRI and neuropsychological findings is possible if quantitative methods are used to distinguish different MS involvement areas in relation to neuropsychological tasks. These findings suggest that hemispheric lesions in MS produce cognitive disturbances and MRI could be a useful tool in predicting memory and learning impairment.

译文

研究了35例确诊的多发性硬化症 (MS) 患者。他们接受了神经心理学测试和磁共振成像 (MRI)。将不同脑区水平的MRI表现与神经心理学表现进行比较。定量系统用于测量MRI-MS病变。在该系列中,通过电池144测量的记忆和学习障碍与通过MRI测量的病变 (总,半球,特别是脑室周围病变) 之间建立了正相关。MRI可以检测MS病变,这项研究表明,如果使用定量方法区分与神经心理学任务有关的不同MS受累区域,则MRI与神经心理学发现之间的相关性是可能的。这些发现表明,MS的半球病变会产生认知障碍,MRI可能是预测记忆和学习障碍的有用工具。

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