A number of brain imaging techniques have been developed in order to investigate brain function and to develop diagnostic tools for various brain disorders. Each modality has strengths as well as weaknesses compared to the others. Recent work has explored how multiple modalities can be integrated effectively so that they complement one another while maintaining their individual strengths. Bayesian inference employing Markov Chain Monte Carlo (MCMC) techniques provides a straightforward way to combine disparate forms of information while dealing with the uncertainty in each. In this paper we introduce methods of Bayesian inference as a way to integrate different forms of brain imaging data in a probabilistic framework. We formulate Bayesian integration of magnetoencephalography (MEG) data and functional magnetic resonance imaging (fMRI) data by incorporating fMRI data into a spatial prior. The usefulness and feasibility of the method are verified through testing with both simulated and empirical data.

译文

已经开发了许多脑成像技术,以研究脑功能并开发针对各种脑部疾病的诊断工具。与其他方式相比,每种方式都有优点和缺点。最近的工作探讨了如何有效地整合多种模式,以便它们在保持各自优势的同时相互补充。采用马尔可夫链蒙特卡洛 (MCMC) 技术的贝叶斯推理提供了一种简单的方法来组合不同形式的信息,同时处理每种信息中的不确定性。在本文中,我们介绍了贝叶斯推理方法,作为在概率框架中集成不同形式的大脑成像数据的一种方法。通过将fMRI数据合并到空间先验中,我们制定了脑磁图 (MEG) 数据和功能磁共振成像 (fMRI) 数据的贝叶斯集成。通过模拟和经验数据的测试,验证了该方法的有效性和可行性。

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