Oscillatory brain activity in the alpha band (8-13 Hz) is modulated by cognitive events. Such modulation is reflected in a decrease of alpha (event-related desynchronization; ERD) with high cognitive load, or an increase (event-related synchronization) with low cognitive demand or with active inhibition of distractors. We used magnetoencephalography to investigate the pattern of prefrontal and parieto-occipital alpha modulation related to two variants of visual working memory task (delayed matching-to-sample) with and without a distractor. We tested nonmedicated, nondepressed patients suffering obsessive-compulsive disorder (OCD), and pair-matched healthy controls. The level of event-related alpha as a function of time was estimated using the temporal-spectral evolution technique. The results in OCD patients indicated: (1) a lower level of prestimulus (reference) alpha when compared to controls, (2) a task-phase specific reduction in event-related alpha ERD in particular for delayed matching-to-sample task with distractor, (3) no significant correlations between the pattern of modulation in prefrontal and parietal-occipital alpha oscillatory activity. Despite showing an abnormally low alpha modulation, the OCD patients' performance accuracy was normal. The results suggest a relationship of alpha oscillations and the underlying thalamocortical network to etiology of OCD and an involvement of a compensatory mechanism related to effortful inhibition of extrinsic and intrinsic interference.

译文

α 波段 (8-13Hz) 的脑振荡活动受认知事件的调节。这种调制反映在具有高认知负荷的alpha降低 (事件相关的去同步; ERD),或具有低认知需求或主动抑制干扰物的增加 (事件相关的同步)。我们使用脑磁图研究了有和没有干扰物的视觉工作记忆任务 (延迟匹配样本) 的两种变体相关的前额叶和顶枕alpha调制模式。我们测试了患有强迫症 (OCD) 的非药物,非抑郁症患者以及配对的健康对照。使用时间光谱演化技术估算事件相关alpha的水平随时间的变化。强迫症患者的结果表明 :( 1) 与对照组相比,刺激前 (参考) α 水平较低,(2) 事件相关的 α ERD的任务阶段特异性降低,特别是对于延迟匹配样本任务与分心器,(3) 前额叶的调节模式与顶叶-枕叶 α 振荡活动之间无显着相关性。尽管显示出异常低的 α 调制,但强迫症患者的表现准确性正常。结果表明,α 振荡和潜在的丘脑皮层网络与OCD的病因之间存在关系,并且参与了与努力抑制外在和内在干扰有关的补偿机制。

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