Using a melt-pressing technique, we produced a small solid cylinder containing cisplatin (CDDP) embedded in poly-d, l-lactic acid (CDDP-PLA). The in vitro release of CDDP from the polymer was examined in an immersion system. CDDP was released continuously for more than four weeks with no initial burst. Drug distribution for CDDP-PLA was compared with CDDP solution (CDDP-SOL) by subcutaneous administration into the back of rats. In the CDDP-PLA group, a high concentration of CDDP was maintained in the subcutaneous tissues near the implants for 20 days. However, in the CDDP-SOL group, the concentration of CDDP was low by 10 days after drug administration. CDDP-PLA may become a useful tool in locoregional chemotherapy as a solid type of drug delivery system with longlasting release.

译文

使用熔融压制技术,我们生产了一个小的固体圆柱体,其中包含嵌入聚d,l-乳酸 (CDDP-PLA) 中的顺铂 (CDDP)。在浸没系统中检查了CDDP从聚合物中的体外释放。CDDP连续发布超过四个星期,没有初始爆发。通过皮下给药到大鼠背部,将CDDP-PLA的药物分布与CDDP溶液 (CDDP-SOL) 进行比较。在cddp-pla组中,在植入物附近的皮下组织中维持高浓度的CDDP 20天。然而,在CDDP-SOL组中,给药后10天CDDP的浓度较低。Cddp-pla作为一种具有持久释放的固体药物输送系统,可能成为局部化疗的有用工具。

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