It is unclear whether overweight but otherwise healthy boys with delayed puberty have a variation of constitutional delay of growth and maturation (CDGM) or a different etiology for their pubertal delay. To characterize better this group of boys and investigate whether their growth pattern distinguishes them from boys with typical CDGM, growth data were analyzed in eight overweight (BMI SDS > or = 85th percentile) and 37 non-overweight (BMI SDS <85th percentile) boys with delayed puberty. Primary outcome measures included predicted height (PH) and adult height (AH). At diagnosis of delayed puberty, the overweight boys had less delayed bone ages (chronological age [CA] - bone age [BA] = 1.2 +/- 1.0 vs 2.5 +/- 1.1 years, p <0.01), greater height SDS for CA (-0.5 +/- 0.7 vs -2.4 +/- 0.8, p <0.001), and greater height SDS for BA (0.6 +/- 0.9 vs -0.4 +/- 1.1, p <0.05). PH for the overweight boys exceeded their mid-parental height (MPH) by 5.0 +/- 7.2 cm while non-overweight boys were predicted to fall below their MPH by 2.8 +/- 6.3 cm (p <0.01). Available AH data corroborated the differences in PH, with a trend for overweight boys to have greater height relative to their MPH than the non-overweight boys. These observations suggest that in the context of delayed puberty, being overweight may modulate adult height and/or that the etiology of delayed puberty in overweight boys may differ from typical CDGM.

译文

尚不清楚青春期延迟的超重但健康的男孩是否存在生长和成熟的体质延迟 (CDGM) 或青春期延迟的不同病因。为了更好地描述这一组男孩,并调查他们的生长模式是否将他们与典型CDGM男孩区分开,对8名超重 (BMI SDS> 或 = 85百分位) 和37名非超重 (BMI SDS <85百分位) 青春期延迟男孩的生长数据进行了分析。主要结局指标包括预测身高 (PH) 和成人身高 (AH)。在诊断青春期延迟时,超重男孩的骨龄延迟较少 (按时间顺序年龄 [CA] -骨龄 [BA] = 1.2/- 1.0 vs 2.5/- 1.1岁,p <0.01),CA的更高高度SDS (-0.5 +/- 0.7 vs -2.4 +/- 0.8,p <0.001),BA的更高高度SDS (0.6 +/- 0.9 vs -0.4 +/- 1.1,p <0.05)。超重男孩的ph值超过其父母中等身高 (MPH) 5.0 +/-7.2厘米,而非超重男孩预计将低于其MPH 2.8 +/-6.3厘米 (p <0.01)。可用的AH数据证实了PH的差异,超重男孩的身高相对于其MPH的趋势比非超重男孩更大。这些观察结果表明,在青春期延迟的情况下,超重可能会调节成人身高和/或超重男孩青春期延迟的病因可能与典型的CDGM不同。

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