To determine the CT findings and assess their diagnostic performance in differentiating early perforated appendicitis from nonperforated appendicitis, and to compare therapeutic approaches and clinical outcomes between two types of appendicitis. Our retrospective study was approved by our institutional review board and informed consent was waived. From July 2012 to July 2013, 339 patients [mean age 40.8 years; age range 19-80 years; 183 male (mean age 40.5 years; age range 19-79 years) and 156 female (mean age 41.2 years; age range 19-80 years)] who underwent appendectomy with preoperative CT examination for suspected acute appendicitis were included, with exclusion of 37 patients with specific CT findings for advanced perforated appendicitis. And they were categorized into nonperforated and early perforated appendicitis groups according to surgical and pathologic reports. The following CT findings were evaluated by two radiologists blinded to pathologic and surgical findings: transverse diameter of the appendix, thickness of the appendiceal wall, the depth of intraluminal appendiceal fluid, appendiceal wall enhancement, presence or absence of focal defect in the appendiceal wall, intraluminal appendiceal air, appendicolith/fecalith, periappendiceal changes, cecal wall thickening, and free fluid. The type of surgical procedures, performance of surgical drainage, and the length of hospital stay were recorded. Univariate and multivariate logistic regression analysis were used to determine the CT findings for differentiating early perforated appendicitis from nonperforated appendicitis, a total of 75 (22%) of the 339 patients was diagnosed with early perforated appendicitis. Focal wall defect [adjusted odds ratio (aOR), 23.40; p < 0.001], circumferential periappendiceal changes (aOR, 5.63; p < 0.001), appendicoliths/fecaliths (aOR, 2.47; p = 0.015), and transverse diameter of the appendix (aOR, 1.22; p = 0.003) were independently differentiating variables for early perforated appendicitis. The transverse diameter of the appendix (≥11 mm) had the highest sensitivity (62.7%) and focal wall defect in the appendiceal wall showed the highest specificity (98.8%). The prevalence of surgical drainage was higher (p = 0.001) and the mean hospital stay was approximately one day longer (p < 0.001) in the early perforated group than nonperforated group. CT can be helpful in differentiating early perforated appendicitis from nonperforated appendicitis, although the sensitivity of the evaluated findings was somewhat limited.

译文

确定CT表现并评估其在区分早期穿孔性阑尾炎和非穿孔性阑尾炎方面的诊断性能,并比较两种类型阑尾炎的治疗方法和临床结果。我们的回顾性研究获得了我们的机构审查委员会的批准,并且放弃了知情同意。从2012年7月到2013年7月,339名患者 [平均年龄40.8岁; 年龄范围19-80岁; 183名男性 (平均年龄40.5岁; 年龄范围19-79岁) 和156名女性 (平均年龄41.2岁; 年龄范围19-80岁)] 包括因疑似急性阑尾炎接受阑尾切除术并进行术前ct检查的患者,其中排除了37例具有特定CT表现的晚期穿孔阑尾炎患者。根据手术和病理报告,将其分为未穿孔和早期穿孔阑尾炎组。由两名对病理和手术结果视而不见的放射科医生评估了以下CT表现: 阑尾的横向直径,阑尾壁的厚度,腔内阑尾液的深度,阑尾壁的增强,阑尾壁中是否存在局灶性缺损,腔内阑尾空气,阑尾/粪便,阑尾周围改变,盲肠壁增厚,游离液体。记录手术类型,手术引流性能和住院时间。采用单因素和多因素logistic回归分析来确定CT表现,以区分早期穿孔性阑尾炎和非穿孔性阑尾炎,总共339例患者中有75例 (22% 例) 被诊断为早期穿孔性阑尾炎。局灶性壁缺损 [调整比值比 (aOR),23.40; p <0.001],周缘阑尾周围变化 (aOR,5.63; p <0.001),阑尾石料/粪便 (aOR,2.47; p = 0.015) 和阑尾横径 (aOR,1.22; p = 0.003) 是早期穿孔性阑尾炎的独立差异变量。阑尾的横向直径 (≥ 11毫米) 具有最高的敏感性 (62.7%),阑尾壁的局部壁缺损显示出最高的特异性 (98.8%)。与未穿孔组相比,早期穿孔组手术引流的发生率更高 (p = 0.001),平均住院时间长约一天 (p <0.001)。尽管评估结果的敏感性有些有限,但CT有助于区分早期穿孔性阑尾炎和非穿孔性阑尾炎。

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