The porcine adenovirus type 3 (PAd3) genome between map units 0 and 13.7 was sequenced and compared with similar regions of other adenoviruses. This region consists of the left inverted terminal repeat sequences involved in DNA packaging, the entire early region 1 (E1) and the protein IX (pIX) transcription unit. The lower strand contains the C-terminal end of IVa2 of the E2A transcriptional unit and two novel open reading frames (ORFs). The E1 transcription unit consists of ORFs for proteins homologous to the E1A, E1B-17k and E1B-55k of both human adenovirus type 5 (HAd5) and bovine adenovirus type 3 (BAd3). The predicted PAd3 pIX demonstrated homology with the N-terminal portion of the pIXs of HAd5 and BAd3. On the lower strand, immediately after the putative IVa2 ORF, there are two unique ORFs of 208 and 203 amino acid residues that showed homology with Epstein-Barr virus nuclear antigens and other cellular transcription factors.

译文

对图谱单位0和13.7之间的猪腺病毒3型 (PAd3) 基因组进行了测序,并与其他腺病毒的相似区域进行了比较。该区域由参与DNA包装的左反向末端重复序列,整个早期区域1 (E1) 和蛋白质IX (pIX) 转录单元组成。下链包含E2A转录单位IVa2的C末端和两个新的开放阅读框 (orf)。E1转录单元由与E1A,E1B-17k和E1B-55k同源的人腺病毒5型 (HAd5) 和牛腺病毒3型 (BAd3) 的蛋白质的orf组成。预测的PAd3 pIX与HAd5和bad3的pIX的N末端部分具有同源性。在下链上,紧接在推定的IVa2 ORF之后,有两个独特的208和203氨基酸残基的ORF,它们与爱泼斯坦-巴尔病毒核抗原和其他细胞转录因子具有同源性。

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