Previous studies have shown that paramedian reticular nucleus (PRN) possessed sympathetic and parasympathetic inhibitions on autonomic nervous system. In the present study, the cardiovascular reactions of PRN by locally-applied DL-homocysteic acid (DLH), acetylcholine (ACh), monoamines and electrophysiological properties of PRN neurons responding to intravenous injection of ACh and NE were studied in adult Sprague-Dawley rats. In PRN, electrical stimulation caused hypotension and mild bradycardia while microinjection of DLH, which excites only cell body of the neurons but not passing fibers, evoked similar responses. Furthermore, direct application of ACh, norepinephrine (NE) or serotonin (5-HT) in PRN also produced hypotension, suggesting that these putative neurotransmitters may be involved in the cardiovascular responses in PRN. The electrophysiological properties of PRN neurons were studied: Neurons in PRN could be categorized into three types according to their neuronal activities in response to the changes of systemic arterial blood pressure (SAP) by ACh or NE given intravenously. Type I neurons (25/69) were activated in the same direction of SAP changes. Type II neurons (17/69) responded opposite to the direction of SAP changes. Type III neurons (27/69) responded inconsistently to the changes of SAP. All the three types of neurons were excited by locally-applied DLH and possessed a similar unfiltered action potential duration of greater than 0.5 msec.

译文

先前的研究表明,正中网状核 (PRN) 对自主神经系统具有交感和副交感神经抑制作用。在本研究中,在成年Sprague-Dawley中研究了局部应用DL-同型半胱氨酸 (DLH),乙酰胆碱 (ACh),单胺和PRN神经元对静脉注射ACh和NE的反应的心血管反应。大鼠。在PRN中,电刺激引起低血压和轻度心动过缓,而微量注射DLH仅激发神经元的细胞体而不通过纤维,引起类似的反应。此外,在PRN中直接应用ACh,去甲肾上腺素 (NE) 或5-羟色胺 (5-HT) 也会产生低血压,这表明这些假定的神经递质可能与PRN的心血管反应有关。研究了PRN神经元的电生理特性: 根据静脉内给药的ACh或NE对全身动脉血压 (SAP) 变化的响应,PRN中的神经元可分为三种类型。I型神经元 (25/69) 在SAP变化的同一方向被激活。II型神经元 (17/69) 对SAP变化的方向相反。III型神经元 (27/69) 对SAP的变化反应不一致。所有三种类型的神经元均由局部应用的DLH激发,并具有大于0.5毫秒的类似的未经过滤的动作电位持续时间。

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