BACKGROUND & AIMS:
:The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 +/- 5.9 vs 88.7 +/- 8.7 microg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 +/- 0.9 vs 0.63 +/- 0.4 mg/dL, p < 0.0001; 2.07 +/- 0.84 vs 1.51 +/- 0.69, p < 0.0001; 9.26 +/- 3.8 vs 6.8 +/- 2.98 microU/MI, p < 0.0001; 15.7 +/- 7.4 vs 11.5 +/- 5.1 micromol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 microg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >or= 80 (n = 91; 1.23 +/- 0.98 vs 0.81 +/- 0.76 mg/dL, p < 0.003; 1.99 +/- 0.88 vs 1.64 +/- 0.74, p < 0.005; 15.0 +/- 7.6 vs 12.9 +/- 5.7 micromol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.
背景与目标:
:本研究旨在根据对照评估糖尿病患者一级亲属(FDR)的血清硒水平。在这些患者中还研究了胰岛素抵抗,血清脂质水平,炎症标志物和血压。 FDR中的血清硒水平显着低于对照组(74.65 /-5.9 vs 88.7 /-8.7 microg / dl,p <0.0001)。根据对照组,FDR中的HsCRP,HOMA-IR,胰岛素,高半胱氨酸水平显着更高(1.32 /-0.9对0.63 /-0.4 mg / dL,p <0.0001; 2.07 /-0.84对1.51 /-0.69,p < 0.0001; 9.26 /-3.8 vs 6.8-2.98 microU / MI,p <0.0001; 15.7 /-7.4 vs 11.5 /-5.1 micromol / L,p <0.0001)。硒水平与hsCRP之间存在显着相关性(r =-0.450,p <0.0001)。 HOMA-IR与硒水平之间也存在弱的显着相关性(r = -0.227,p = 0.003)。收缩压与BMI之间存在相关性(r = 0.365,p <0.0001)。但是硒水平与血压或其他参数之间没有相关性。硒水平<80 microg / L(n = 78)的个体中的HsCRP,HOMA-IR,高半胱氨酸水平显着高于硒水平>或= 80的hsCRP HOMA-IR,高半胱氨酸水平(n = 91; 1.23 / -0.98对0.81 /-0.76 mg / dL,p <0.003; 1.99 /-0.88对1.64 /-0.74,p <0.005; 15.0 /-7.6对12.9 /-5.7 micromol / L,p <0.049)。硒缺乏可能会导致FDR患心血管疾病。