The aim of this study was to evaluate patient-reported outcomes of Collagenase Clostridium Histolyticum (CCHi) for Peyronie's Disease. Patients treated with 2-4 cycles of CCHi between 01/2016 and 08/2018 were asked to fill out the "bother domain" of the Peyronie's Disease Questionnaire (PDQ) at scheduled appointments for injections. CCHi cycles involved two injections (0.58 mg) separated by 48-72 hr. During the study, 34 patients were treated, seven patients were excluded due to incomplete baseline values. Mean (standard deviation) PDQ bother domain baseline score was 11.1 (2.6). ANOVA demonstrated statistically significant effects of injections (p < .001) with a decrease in PDQ bother domain scores 6 weeks after the 1st cycle (9.9 [3.3], p = .013), 6 weeks after the 2nd cycle (8.2 [4.0], p = .009) and 6 weeks after the 3rd cycle (6.5 [3.6], p < .001). After 2-4 cycles of CCHi treatment, patients reported changes in penile curvature as "Worse" (0), "No Change" (2), "Little decrease" (10), Decrease (10) and "Significant decrease" (4). After completion of CCHi treatment, 82% of patients still reported that vaginal intercourse was difficult or impossible. Patients with Peyronie's Disease undergoing CCHi treatment reported statistically significant decreases in PDQ bother domain scores. However, most patients still report difficulty with intercourse after treatment.

译文

这项研究的目的是评估患者报告的胶原酶溶组织梭状芽胞杆菌 (CCHi) 治疗佩罗尼氏病的结果。要求在01/2016至08/2018之间接受2-4个周期的CCHi治疗的患者在预定的注射预约时填写佩罗尼氏病问卷 (PDQ) 的 “困扰域”。CCHi循环涉及两次注射 (0.58 mg),间隔48-72小时。在研究期间,34例患者接受了治疗,7例患者由于基线值不完整而被排除在外。平均 (标准差) PDQ干扰域基线评分为11.1 (2.6)。方差分析显示,在第1周期后6周 (9.9 [3.3],p = .013),第2周期后6周 (8.2 [4.0]),PDQ干扰域得分降低,注射具有统计学意义 (p <.001),p = .009) 和第3周期后6周 (6.5 [3.6],p <.001)。经过2-4个周期的CCHi治疗后,患者报告阴茎弯曲的变化为 “恶化” (0),“无变化” (2),“几乎减少” (10),减少 (10) 和 “显着减少” (4)。完成CCHi治疗后,仍有82% 患者报告阴道性交困难或不可能。接受CCHi治疗的佩罗尼氏病患者报告PDQ干扰域得分在统计学上显着降低。然而,大多数患者在治疗后仍然报告性交困难。

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