Male breast cancer (MBC) is an uncommon neoplasm that shares several biologic characteristics with its female counterpart. In the latter, abnormalities in the expression and/or copy number of the ERBB2 gene are present in 10% to 30% of invasive carcinoma and behave as poor prognostic markers. ERBB2 abnormalities have also been reported in MBC, yet at lower frequency, but their prognostic significance remains controversial. Furthermore, no study has addressed the impact of chromosome 17 abnormalities in MBC survival. In this study, the ERBB2-gene status (overexpression and amplification) and chromosome 17 numerical abnormalities were investigated in a series of 50 archival cases of MBC. The results, together with patient's age, histologic grade, pathologic stage, and estrogen receptor status were correlated with overall survival. ERBB2-protein overexpression was present in 7 cases (14%), ERBB2-gene amplification in 4 (8%), and aneuploidy of chromosome 17 in 12 cases (33.3%). The pathologic stage, ERBB2 overexpression and ERBB2 amplification were significantly correlated with overall survival (P=0.002, 0.016, and 0.009, respectively). No correlation was observed between chromosome 17 aneuploidy and overall survival. Therefore, despite their low incidence in MBC, expression abnormalities of ERBB2 behave, together with the pathologic stage of the tumor, as predictors of overall survival, akin to what has been reported for its female counterpart.

译文

男性乳腺癌 (MBC) 是一种罕见的肿瘤,与女性具有多种生物学特征。在后者中,ERBB2基因的表达和/或拷贝数的异常存在于10% 浸润性癌的30% 中,并且表现为不良的预后标志物。在MBC中也有ERBB2异常的报道,但频率较低,但其预后意义仍存在争议。此外,还没有研究涉及17号染色体异常对MBC存活的影响。在这项研究中,在一系列50例MBC档案病例中研究了ERBB2-gene状态 (过表达和扩增) 和17号染色体数字异常。结果以及患者的年龄,组织学分级,病理分期和雌激素受体状态与总生存率相关。ERBB2-protein过表达7例 (14%),ERBB2-gene扩增4例 (8%),17号染色体非整倍性12例 (33.3%)。病理分期,ERBB2过表达和ERBB2扩增与总生存期显着相关 (分别为P = 0.002,0.016和0.009)。在17号染色体非整倍性与总生存率之间未观察到相关性。因此,尽管ERBB2在MBC中的发生率较低,但其表达异常与肿瘤的病理阶段一起表现为总体生存的预测指标,类似于已报道的女性对应物。

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