Self-injurious behavior is a common problem in many developmental disorders. The neurobiology of this behavior is not well understood, but the differing behavioral manifestations and associations with different disorders suggest that the underlying biological mechanisms are heterogeneous. The behavioral and biological heterogeneity is also evident in several animal models, where different manifestations can be provoked under different experimental conditions. Identifying commonalities among the different mechanisms is likely to be helpful in the design of treatments useful for the broadest populations of patients. The current studies reveal that nifedipine suppresses self-injurious behavior in 4 unrelated animal models: acute administration of high doses of +/-BayK 8644 or methamphetamine in mice, dopamine agonist treatment in rats with lesions of dopamine pathways during early development and repeated administration of pemoline in rats. The effect of nifedipine does not appear to be due to nonspecific mechanisms, such as sedation, since other classes of behaviors are unaffected or exaggerated. These results suggest that nifedipine may target a common biological mechanism in the expression of self-injurious behavior, and they suggest it should be considered in the treatment of self-injury in humans.

译文

自残行为是许多发育障碍的常见问题。这种行为的神经生物学尚未得到很好的理解,但是不同的行为表现和与不同疾病的关联表明潜在的生物学机制是异质的。在几种动物模型中,行为和生物学的异质性也很明显,在不同的实验条件下,可以引起不同的表现形式。确定不同机制之间的共同点可能有助于设计对最广泛的患者群体有用的治疗方法。目前的研究表明,硝苯地平可抑制4种无关动物模型的自我伤害行为: 在小鼠中急性施用高剂量的/-BayK 8644或甲基苯丙胺,在早期发育过程中多巴胺途径损伤的大鼠中进行多巴胺激动剂治疗以及反复施用匹莫林在大鼠中。硝苯地平的作用似乎不是由于非特异性机制 (例如镇静) 引起的,因为其他类别的行为不受影响或被夸大。这些结果表明,硝苯地平可能针对自我伤害行为表达中的常见生物学机制,并且建议在治疗人类自我伤害时应考虑硝苯地平。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录