Thymohexine treatment of intact CFU-S was shown not to change their capacity to form colonies both in vivo and in vitro. Thymohexine, similarly to thymus cells, increased colony yield from rabbit antimouse brain antiserum (RAMBS)-treated bone marrow. Combined treatment with thymohexine and thymocytes did not restore colony formation by RAMB serum-treated bone marrow. Thymohexine halved the harmful effect of low doses of ionizing radiation on CFU-S, and, moreover, treatment with the peptide after 4 Gy-irradiation led to more intensive restoration of CFU-S population as compared to control.

译文

胸腺己烷处理完整的CFU-S并未改变其在体内和体外形成菌落的能力。与胸腺细胞类似,胸腺己烷增加了兔抗鼠脑抗血清 (RAMBS) 处理的骨髓的集落产量。胸腺己烷和胸腺细胞联合治疗不能通过RAMB血清处理的骨髓恢复菌落形成。百里酮可减少低剂量电离辐射对CFU-S的有害作用,此外,与对照组相比,在4 Gy辐射后用该肽处理可使CFU-S种群恢复得更加密集。

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