Sound whole-seed faba beans were treated with (methyl-(14)C) fenitrothion [O, O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate] at 5 and 10 mg insecticide/kg seeds, a dose normally used in practice. During the 30 weeks of storage period, the penetration and distribution of insecticide residues were studied. The amount of surface residues, internal residues and bound insecticide residues was estimated. Surface residues were found to decrease with the increase in time of storage, whereas internal residues showed a gradual increase with time apparently not dose dependent. Grain-bound residues increased with time and reached to its maximum (14-18%) after 24 weeks of storage. Chromatographic analysis of the internal extracts revealed the presence of the parent compound together with three main metabolites which were found in both free and conjugated form. Feeding mice for 90 days with a diet mixed with total internal fenitrothion residues in stored faba beans led to a reduction in body weight gain, and an appreciable decrease in cholinesterase activity of 32% for plasma and 15% for red blood cells (RBC(S)) after two months of experiment. Also, a significant decrease was showed in both total protein and albumin concentration at the end of feeding period (90 days). Liver and kidney function, as well as lipid profile of treated mice significantly increased at the end of feeding period. After a one-month recovery period, all the examined blood parameters returned to about the control values except blood urea and serum triglyceride.

译文

用 (甲基-(14)C) 杀nitro硫磷 [O,O-二甲基-O-(3-甲基-4-硝基苯基) 硫代磷酸酯] 以5和10 mg杀虫剂/kg种子处理全种子蚕豆,该剂量通常在实践中使用。在30周的储存期间,研究了杀虫剂残留物的渗透和分布。估算了表面残留物,内部残留物和结合的杀虫剂残留物的数量。发现表面残留物随储存时间的增加而减少,而内部残留物随时间逐渐增加,显然与剂量无关。谷物结合残留物随时间增加,并在储存24周后达到最大值 (14-18%)。内部提取物的色谱分析表明,存在母体化合物以及三种主要代谢物,它们均以游离和共轭形式存在。在两个月的实验后,用与储存的蚕豆中的总内部杀nitro离子残基混合的饮食喂养小鼠90天,导致体重增加减少,并且32% 对血浆和对红细胞 (RBC(S)) 的15% 胆碱酯酶活性明显降低。此外,在饲喂期结束时 (90天),总蛋白和白蛋白浓度均显着降低。在喂养期结束时,治疗小鼠的肝,肾功能以及脂质分布显着增加。经过一个月的恢复期后,除血尿素和血清甘油三酸酯外,所有检查的血液参数均恢复到约对照值。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录