The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity toward experimental legionellosis and listeriosis was studied. Immunisation with tularemia vaccine protected over 80% and 17% of experimental animals against subsequent lethal challenge with Legionella pneumophila and Listeria monocytogenes, respectively. The protection was maximal during the first month following immunisation and declined thereafter. In order to delineate the immunostimulatory moieties of the Francisella microbe, several cell wall proteins have been purified and characterized. However, isolated cell wall components failed to induce protection.

译文

研究了活的土拉弗朗西斯菌疫苗株对实验性军团菌病和李斯特菌病产生非特异性免疫的功效。用tularemia疫苗免疫分别保护了超过80% 和17% 的实验动物免受随后的嗜肺军团菌和单核细胞增生李斯特菌的致命攻击。在免疫后的第一个月,保护作用最大,此后下降。为了描述Francisella微生物的免疫刺激部分,已经纯化并鉴定了几种细胞壁蛋白。然而,孤立的细胞壁成分未能诱导保护。

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