Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the architecture of a hidden set of polo boxes from the divergent PLK4, a critical player in centrosome duplication, shedding new light on the evolution of PLKs and their functionally related kinase ZYG-1.
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【Polo boxes come out of the crypt: a new view of PLK function and evolution.].
【Polo盒子从地穴中出来: PLK功能和进化的新视角。】
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DOI：10.1016/j.str.2012.10.008文章类型：杂志文章
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Polo样激酶 (plk) 由C末端polo盒模块标记，具有关键的蛋白质相互作用和亚细胞靶向作用。Slevin等人在本期《结构》中揭示了来自不同PLK4的一组隐藏的polo盒子的架构，PLK4是中心体复制的关键参与者，为plk及其功能相关激酶ZYG-1的演变提供了新的启示。
