Oxidation of low density lipoproteins (LDL) favours cholesterol loading in macrophages and formation of "foam cells", typical of the early atheroma lesions. LDL cholesterol oxidation generates oxysterols, extremely cytotoxic molecular species with diverse biological activities. Vegetable polyphenols are dietary components of pharmacological interest for their anti-oxidant properties. Ginkgo biloba L. (Gingkoaceae) leaves and Vaccinium myrtillus L. (Ericaceae) fruits are known for their beneficial effects in the treatment of various diseases involving free radicals and oxidative damage to biological lipids. In this study we investigated the effect of Ginkgo biloba L. and Vaccinium myrtillus L. extracts on the formation of cholesterol oxides during the photo induced oxidation of human LDL. The results demonstrate a concentration dependent inhibition of oxysterol formation in the presence of both extracts. Protection against oxidation was confirmed by the partial restoration of the normal electrophoretic mobility of LDL, which has been influenced by the UV irradiation. These effects extend knowledge of the therapeutic action of Ginkgo biloba L. and Vaccinium myrtillus L. as agents in anti-atherosclerotic regimens.

译文

低密度脂蛋白 (LDL) 的氧化有利于巨噬细胞中的胆固醇负荷和 “泡沫细胞” 的形成,这是早期动脉粥样硬化病变的典型特征。LDL胆固醇氧化生成氧固醇,具有多种生物活性,具有极强的细胞毒性分子。植物多酚因其抗氧化特性而具有药理学意义的饮食成分。银杏L.(银杏科) 叶子和越橘桃金娘。(Ericaceae) 水果以其在治疗涉及自由基和对生物脂质的氧化损伤的各种疾病中的有益作用而闻名。在这项研究中,我们研究了银杏叶和桃花越橘提取物在光诱导的人LDL氧化过程中对胆固醇氧化物形成的影响。结果表明,在两种提取物的存在下,氧固醇形成的浓度依赖性抑制作用。LDL正常电泳迁移率的部分恢复证实了抗氧化作用,这已受到紫外线照射的影响。这些作用扩展了银杏叶和桃花越橘作为抗动脉粥样硬化治疗药物的治疗作用的知识。

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