It has been proposed that follistatin can modulate the actions of activins and/or other members of the transforming growth factor-beta superfamily of proteins on testicular function, since mice overexpressing follistatin showed spermatogenic disruption. However, since mice with targeted disruption of the follistatin gene die soon after birth, it is not feasible to determine the effect of the absence of follistatin on testicular function using this model. To further understand the role of follistatin on the development and maintenance of spermatogenesis, fetal testes, collected by Caesarean section at day 18 of gestation from follistatin null mice, were transplanted to the external ear of castrated recombination activating gene 1 immunocompromised male mice. The testicular grafts were then analysed 7-8 weeks after transplantation and showed that full spermatogenesis developed in both the testes of wild-type and follistatin null mice. This study indicates that, if follistatin is required to modulate spermatogenic development, it is not supplied by local testicular production but by circulating follistatin from the host mouse.

译文

已经提出,卵泡抑素可以调节激活素和/或蛋白质的转化生长因子-β 超家族的其他成员对睾丸功能的作用,因为过度表达卵泡抑素的小鼠表现出生精破坏。但是,由于具有靶向破坏卵泡抑素基因的小鼠在出生后不久就死亡,因此使用该模型确定不存在卵泡抑素对睾丸功能的影响是不可行的。为了进一步了解卵泡抑素在精子发生的发展和维持中的作用,将卵泡抑素无效小鼠在妊娠第18天通过剖腹产收集的胎儿睾丸移植到去势重组激活基因1免疫功能低下的雄性小鼠的外耳。然后在移植后7-8周对睾丸移植物进行分析,结果表明,野生型和卵泡抑制素无效小鼠的睾丸均发育了完全的精子发生。这项研究表明,如果需要卵泡抑素来调节生精发育,则不是由本地睾丸产生而是由宿主小鼠循环卵泡抑素提供的。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录