Limb-girdle muscular dystrophies (LGMDs) are common in India. Information on LGMDs has been gradually evolving in the recent years. This information is scattered in case series and case studies. The aim of this study is to collate available Indian information on LGMDs and put it in perspective. PubMed search using keywords such as limb-girdle muscular dystrophies in India, sarcoglycanopathies, dysferlinopathy, calpainopathy, and GNE myopathy was carried out. The published information on LGMDs in Indian context suggests that dysferlinopathy, calpainopathy, sarcoglycanopathies, and other myopathies such as GNE myopathy are frequently seen in India. Besides these, anecdotal reports of many other forms are available, some with genetic support and others showing immunocytochemical defects. The genotypic information on LGMDs is gradually evolving and founder mutations have been detected in selected populations. Further multicenter studies are necessary to document the incidence and prevalence of these common conditions in India.

译文

肢带性肌营养不良症 (lgmd) 在印度很常见。近年来,关于lgmd的信息正在逐步发展。这些信息分散在案例系列和案例研究中。这项研究的目的是整理有关lgmd的印度现有信息,并加以透视。进行了PubMed搜索,使用了诸如印度的肢带性肌营养不良,肌糖病,失铁线病,calpainopathy和GNE肌病等关键词。在印度,有关lgmd的公开信息表明,在印度经常出现运动障碍病,钙蛋白酶病,肌糖病和其他肌病,例如GNE肌病。除此之外,还提供了许多其他形式的轶事报告,其中一些具有遗传支持,而另一些则显示出免疫细胞化学缺陷。有关lgmd的基因型信息正在逐步发展,并且已在选定的人群中检测到创始人突变。需要进一步的多中心研究来记录印度这些常见疾病的发生率和患病率。

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