BACKGROUND:There are few approved therapies for adults with attention-deficit/hyperactivity disorder (ADHD) in Europe. Lisdexamfetamine (LDX) is an effective treatment for ADHD; however, no clinical trials examining the efficacy of LDX specifically in European adults have been conducted. Therefore, to estimate the efficacy of LDX in European adults we performed a meta-regression of existing clinical data. METHODS:A systematic review identified US- and Europe-based randomized efficacy trials of LDX, atomoxetine (ATX), or osmotic-release oral system methylphenidate (OROS-MPH) in children/adolescents and adults. A meta-regression model was then fitted to the published/calculated effect sizes (Cohen's d) using medication, geographical location, and age group as predictors. The LDX effect size in European adults was extrapolated from the fitted model. Sensitivity analyses performed included using adult-only studies and adding studies with placebo designs other than a standard pill-placebo design. RESULTS:Twenty-two of 2832 identified articles met inclusion criteria. The model-estimated effect size of LDX for European adults was 1.070 (95% confidence interval: 0.738, 1.401), larger than the 0.8 threshold for large effect sizes. The overall model fit was adequate (80%) and stable in the sensitivity analyses. CONCLUSION:This model predicts that LDX may have a large treatment effect size in European adults with ADHD.

译文

背景:在欧洲,针对成人注意力不足/多动障碍(ADHD)的成人认可的疗法很少。 Lisdexamfetamine(LDX)是治疗ADHD的有效方法;但是,尚未进行过专门研究LDX在欧洲成人中的疗效的临床试验。因此,为了评估LDX在欧洲成人中的疗效,我们对现有临床数据进行了荟萃回归。
方法:系统评价确定了基于美国和欧洲的LDX,阿托西汀(ATX)或渗透释放口服哌醋甲酯(OROS-MPH)在儿童/青少年和成人中的随机疗效试验。然后使用药物,地理位置和年龄组作为预测因子,将荟萃回归模型拟合到已发布/计算出的效应量(Cohen d)。欧洲成年人的LDX效应大小是从拟合模型中推算出来的。进行的敏感性分析包括仅使用成人的研究,以及使用标准药丸-安慰剂设计以外的安慰剂设计进行的研究。
结果:2832篇已鉴定文章中有22篇符合纳入标准。欧洲成年人LDX的模型估计效应大小为1.070(95%置信区间:0.738、1.401),大于大效应大小的0.8阈值。总体模型拟合良好(80%),灵敏度分析稳定。
结论:该模型预测LDX在欧洲成人ADHD中可能具有较大的治疗效果。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录