OBJECTIVE:To evaluate stimulant medication on symptoms and functioning for college students with ADHD using double-blind, placebo-controlled, crossover design. METHOD:Participants included 24 college students with ADHD and 26 college students without psychopathology. Lisdexamfetamine dimesylate (LDX) was examined for ADHD participants over five weekly phases (no-drug baseline, placebo, 30-, 50-, and 70-mg LDX per day). Self-report rating scales of functioning and direct assessment of ADHD symptoms, verbal learning/memory, and adverse side effects were collected (baseline only for control students). RESULTS:LDX was associated with large reductions in ADHD symptoms and improvement in executive functioning along with smaller effects for psychosocial functioning. Reduction in ADHD symptoms was found for 86.4% of participants; however, large differences in symptoms and executive functioning remained relative to controls. CONCLUSION:LDX is a safe, efficacious treatment for symptom relief in college students with ADHD. Research documenting medication effects on academic functioning and evaluating psychosocial/educational interventions is needed.

译文

目的:使用双盲,安慰剂对照,交叉设计评估兴奋性药物对多动症大学生的症状和功能的影响。
方法:参与者包括24名患有ADHD的大学生和26名无精神病理学的大学生。在五个星期的阶段(无药物基线,安慰剂,每天30、50和70 mg LDX)检查了AD参与者中的Lsdexamfetamine dimesylate(LDX)。收集自我功能的评估量表,并直接评估ADHD症状,言语学习/记忆和不良副作用(仅针对对照学生作为基线)。
结果:LDX与ADHD症状的大量减轻和执行功能的改善以及对心理社会功能的影响较小有关。发现86.4%的参与者的ADHD症状有所减轻;但是,与对照组相比,症状和执行功能仍存在较大差异。
结论:LDX是一种治疗ADHD大学生症状的安全,有效的方法。需要研究记录药物对学术功能的影响并评估社会心理/教育干预措施。

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