Lipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications.

译文

:脂质囊泡在制药和生物医学工程,新型材料和纳米技术等领域都受到了广泛的关注。基于微流体的脂质体合成与更传统的合成方法(例如挤出和超声处理)相比,具有许多优势。一种这样的微流体方法是微流体流体动力聚焦(MHF),其已经用于合成各种脂质的纳米颗粒和囊泡。我们在这里显示此方法可用于合成大小可控制的1-棕榈酰基-2-油酰基-sn-甘油-3-磷酸胆碱(POPC)囊泡。由于POPC是细胞膜的主要成分之一,因此这项工作可直接应用于生物系统的建模以及具有更高生物相容性的纳米容器在制药和医疗应用中的开发。

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