To determine the efficacy and safety of adding ezetimibe to maximally tolerated lipid lowering therapy in patients with HIV dyslipidemia. Retrospective analysis of lipid parameters was conducted for 33 patients with HIV who had been prescribed ezetimibe 10 mg per day. Mean total cholesterol was reduced 21% (p < 0.001). Mean LDL was reduced 35% (p < 0.001). Mean HDL increased 8% (p = 0.038). Mean triglyceride was reduced 34% (p = 0.006). Mean Apolipoprotein B100 was reduced 33% (p = 0.043). No adverse events occurred. Ezetimibe appears safe and effective in patients with HIV when added to maximally tolerated doses of lipid lowering therapy.

译文

:为了确定在HIV血脂异常患者中最大耐受性降脂治疗中添加依折麦布的疗效和安全性。回顾性分析了33名HIV病人,这些病人每天服用处方依泽替米贝10 mg。平均总胆固醇降低了21%(p <0.001)。平均LDL降低了35%(p <0.001)。平均HDL增加8%(p = 0.038)。平均甘油三酸酯减少了34%(p = 0.006)。平均载脂蛋白B100降低了33%(p = 0.043)。没有发生不良事件。当加入最大耐受剂量的降脂治疗时,依泽替米贝在HIV患者中似乎是安全有效的。

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