Glycolytic cancers are resistant to many forms of chemotherapy and some respond poorly to differentiation therapies. Here, we investigate the effects of exposure to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) on differentiation and cell survival in the human leukemia cell line, HL60 and its mitochondrial gene knockout mutant, HL60rho0. Glycolytic HL60rho0 cells exposed to single and combined treatments expressed less CD15, in most cases, but produced a stronger respiratory burst than parental HL60 cells. HL60rho0 cells were also significantly more resistant to apoptosis after combined ATO+ATRA treatment compared with HL60 cells, and this was associated with failure to upregulate Fas expression.

译文

:糖酵解性癌症对多种形式的化学疗法都有抵抗力,有些对分化疗法反应差。在这里,我们研究了暴露于全反式维甲酸(ATRA)和三氧化二砷(ATO)对人白血病细胞系HL60及其线粒体基因敲除突变体HL60rho0的分化和细胞存活的影响。在大多数情况下,暴露于单一治疗和联合治疗的糖酵解HL60rho0细胞表达的CD15较少,但与亲代HL60细胞相比,产生的呼吸爆发更强。 HL60rho0细胞在ATO ATRA联合治疗后对凋亡的抵抗力也比HL60细胞高得多,这与无法上调Fas表达有关。

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