INTRODUCTION:Apoptosis (programmed cell death) is the best described mode of physiological cell death. During embryonal development and morphogenesis, apoptosis may be induced by two pathways. The first is external protein signal originating from other cell--also named as "death signal". Another one is specific cell reaction for external stress factors. Blood concentration of proteins regulating both pathways of apoptosis may be useful in early diagnosis and staging of thyroid tumors. The aim of study was evaluation of p53 and sFasL blood concentration in patients with benign follicular adenoma and follicular thyroid cancer. MATERIALS AND METHODS:The study population was composed of 28 patients: 14 with thyroid carcinoma and 14 patients with follicular neoplasm (NF). All patients underwent surgical treatment. P53 and sFasL levels were evaluated before surgery and related to the histopathological diagnosis obtained post-surgery. RESULTS:The analysis revealed high sFasL blood concentration in patients with follicular thyroid cancer in comparison with the group with follicular adenoma. There was no statistically significant difference between levels of p53 in both groups. CONCLUSIONS:Evaluation of sFasL serum level concentration may be useful in preoperative diagnosis of follicular thyroid tumors.

译文

简介:细胞凋亡(程序性细胞死亡)是描述性的生理性细胞死亡方式。在胚胎发育和形态发生过程中,可能通过两种途径诱导细胞凋亡。第一个是源自其他细胞的外部蛋白质信号-也称为“死亡信号”。另一个是针对外部应激因素的特异性细胞反应。调节细胞凋亡的两种途径的蛋白质的血药浓度可能对甲状腺肿瘤的早期诊断和分期有用。研究的目的是评估良性滤泡性腺瘤和滤泡性甲状腺癌患者的p53和sFasL血药浓度。
材料与方法:研究人群由28例患者组成:14例甲状腺癌和14例滤泡性肿瘤(NF)。所有患者均接受手术治疗。在手术前评估P53和sFasL水平,并与手术后获得的组织病理学诊断有关。
结果:分析显示,与滤泡性腺瘤相比,滤泡性甲状腺癌患者的sFasL血药浓度较高。两组中p53水平之间无统计学差异。
结论:血清sFasL水平的评估可能对甲状腺滤泡性肿瘤的术前诊断有帮助。

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