The dihydropyridine calcium channel blocker lercanidipine and the ACE inhibitor enalapril are frequently used in the treatment of hypertensive patients. In April 2007, a fixed-dose combination of the two drugs was approved in Germany for the treatment of patients not responding to monotherapy. It is expected that the drug will soon be available in the other European Union markets. In this review the present literature is summarized. Two doses will be available with 10 mg lercanidipine each and 10 or 20 mg enalapril. The medication should be taken once daily, optimally =15 minutes before a meal and the consumption of grapefruit juice should be avoided. The fixed-dose combination of the two drugs has a stronger blood pressure-lowering effect than monotherapy with 20 mg enalapril or 10 mg lercanidipine. The combination is well tolerated and few patients stopped the treatment because of side effects. As expected, the most common side effects reported are cough, peripheral edema, flushing, dizziness and vertigo, occurring in 1-5% of patients. This new fixed-dose combination is a useful adjunct to the present treatment and should increase compliance and help reduce hypertension-related costs.

译文

:二氢吡啶类钙通道阻滞剂乐卡地平和ACE抑制剂依那普利常用于高血压患者的治疗。 2007年4月,这两种药物的固定剂量组合在德国获准用于治疗对单一疗法无反应的患者。预计该药物将很快在其他欧盟市场上销售。在这篇综述中,对现有文献进行了总结。两剂将分别含10毫克lercanidipine和10或20毫克依那普利。药物应每天服用一次,最好=饭前15分钟,并且应避免食用葡萄柚汁。与20 mg依那普利或10 mg lercanidipine的单药治疗相比,两种药物的固定剂量组合具有更强的降血压作用。该组合耐受性好,几乎没有患者因副作用而停止治疗。与预期的一样,所报告的最常见的副作用是咳嗽,周围水肿,潮红,头晕和眩晕,发生于1%至5%的患者中。这种新的固定剂量组合是目前治疗的有用辅助手段,应增加依从性并有助于减少高血压相关的费用。

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